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218718 Casein Kinase II Inhibitor VI, TMCB - CAS 905105-89-7 - Calbiochem

218718
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₁H₉Br₄N₃O₂905105-89-7

Products

Catalogue NumberPackaging Qty/Pack
218718-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708) analog that acts as a highly selective (IC50 >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC50 = 500 nM; Ki = 250 nM) and ERK8 (IC50 = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.
Catalogue Number218718
Brand Family Calbiochem®
SynonymsERK8 Inhibitor I, 4,5,6,7-Tetrabromo-2-dimethylamino-1-carboxymethyl-benzimidazole, K66, Erk Inhibitor VI
References
ReferencesPagano, M.A., et al. 2008. Biochem. J. 415, 353.
Product Information
CAS number905105-89-7
FormWhite powder
Hill FormulaC₁₁H₉Br₄N₃O₂
Chemical formulaC₁₁H₉Br₄N₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Casein Kinase II Inhibitor VI, TMCB - CAS 905105-89-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Casein Kinase II Inhibitor VI, TMCB - CAS 905105-89-7 - Calbiochem Certificates of Analysis

TitleLot Number
218718

References

Reference overview
Pagano, M.A., et al. 2008. Biochem. J. 415, 353.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-February-2012 RFH
SynonymsERK8 Inhibitor I, 4,5,6,7-Tetrabromo-2-dimethylamino-1-carboxymethyl-benzimidazole, K66, Erk Inhibitor VI
DescriptionA cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708) analog that acts as a highly selective (IC50 >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC50 = 500 nM; Ki = 250 nM) and ERK8 (IC50 = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number905105-89-7
Chemical formulaC₁₁H₉Br₄N₃O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (13.3 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesPagano, M.A., et al. 2008. Biochem. J. 415, 353.