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264155 Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

264155
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₃₀H₄₁FN₄O₁₂210344-95-9

Products

Catalogue NumberPackaging Qty/Pack
264155-1MG Plastic ampoule 1 mg
264155-250UG Plastic ampoule 250 μg
Description
OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
Catalogue Number264155
Brand Family Calbiochem®
SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
References
ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Product Information
CAS number210344-95-9
ATP CompetitiveN
FormWhite to slightly brown solid
Hill FormulaC₃₀H₄₁FN₄O₁₂
Chemical formulaC₃₀H₄₁FN₄O₁₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationCaspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.
Biological Information
Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10
Purity≥90% by TLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem Certificates of Analysis

TitleLot Number
264155

References

Reference overview
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
  • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision31-March-2011 RFH
    SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
    DescriptionA potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.
    FormWhite to slightly brown solid
    CAS number210344-95-9
    Chemical formulaC₃₀H₄₁FN₄O₁₂
    Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
    Structure formulaStructure formula
    Purity≥90% by TLC
    SolubilityDMSO (5 mg/ml)
    Storage -20°C
    Protect from moisture
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
    Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
    Nicholson, D.W. 1996. Nature Biotech. 14, 297.
    Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
    Nicholson, D.W., et al. 1995. Nature 376, 37.
    Citation
  • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.