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218806 Caspase Inhibitor Set III - Calbiochem

218806
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Products

Catalogue NumberPackaging Qty/Pack
218806-1SET Glass bottle 1 set
Description
OverviewA set of eight ready to use cell-permeable, irreversible inhibitors of various caspase-family proteases. Contains 25 µl (2 mM) each of Caspase-1 Inhibitor VI, Z-YVAD-FMK (Cat. No. 218746); Caspase-2 Inhibitor I, Z-VDVAD-FMK (Cat. No. 218744); Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 218753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 218757); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No. 218761); and Caspase Inhibitor I, Z-VAD-FMK (Cat. No. 627610). Supplied with a data sheet.
Catalogue Number218806
Brand Family Calbiochem®
References
ReferencesHumke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Product Information
FormLiquid
FormulationSupplied as 2 mM in DMSO.
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetCaspase-1, caspase-2, caspase-3, caspase-4, caspase-5, caspase-6, caspase-7, caspase-8
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Caspase Inhibitor Set III - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase Inhibitor Set III - Calbiochem Certificates of Analysis

TitleLot Number
218806

References

Reference overview
Humke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Thornberry, N.A., et al. 1992. Nature 356, 768.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-January-2008 RFH
DescriptionApoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.

Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible and cell-permeable. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
FormLiquid
FormulationSupplied as 2 mM in DMSO.
Storage -20°C
Protect from moisture
Do Not Freeze Ok to freeze
Toxicity Irritant
ReferencesHumke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Thornberry, N.A., et al. 1992. Nature 356, 768.