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217713 Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

217713
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₈H₂₂N₆O₃S444722-95-6

Products

Catalogue NumberPackaging Qty/Pack
217713-1MG Plastic ampoule 1 mg
217713-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable 2,6-disubstituted purine compound that displays antiproliferative properties. Acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM). Displays greater selectivity for Cdk1/2 over other kinases tested (IC50 = 600 nM, 800 nM, 900 nM and 1.6 µM for ROCKII, PDK1, DYRK1A and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth with a GI50 of 8 µM.
Catalogue Number217713
Brand Family Calbiochem®
Synonyms6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
References
ReferencesHardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.
Product Information
CAS number444722-95-6
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₈H₂₂N₆O₃S
Chemical formulaC₁₈H₂₂N₆O₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk1/cyclin B, Cdk2/cyclin A3
Primary Target IC<sub>50</sub>9.5 nM, 5.4 nM against Cdk1/cyclin B, Cdk2/cyclin A3, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem Certificates of Analysis

TitleLot Number
217713

References

Reference overview
Hardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
DescriptionA cell-permeable purine analog that displays anti-proliferative properties and acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM, respectively). Displays greater selectivity for Cdk's over other kinases tested (IC50 = 30 nM, 600 nM, 800 nM, 900 nM, and 1.6 µM for Cdk2/A, ROCKII, PDK1, DYRK1A, and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth (GI50 of 8 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number444722-95-6
Chemical formulaC₁₈H₂₂N₆O₃S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (20 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesHardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.