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217720 Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem

217720
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₉H₇N₅40254-90-8

Products

Catalogue NumberPackaging Qty/Pack
217720-5MG Plastic ampoule 5 mg
Description
OverviewA 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC50 = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM).
Catalogue Number217720
Brand Family Calbiochem®
Synonyms3-Amino-1H-pyrazolo[3,4-b]quinoxaline
References
ReferencesOrtega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177.
Product Information
CAS number40254-90-8
ATP CompetitiveN
FormRed solid
Hill FormulaC₉H₇N₅
Chemical formulaC₉H₇N₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk1/cyclin B, Cdk5/p25
Primary Target IC<sub>50</sub>0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem Certificates of Analysis

TitleLot Number
217720

References

Reference overview
Ortega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-October-2007 RFH
Synonyms3-Amino-1H-pyrazolo[3,4-b]quinoxaline
DescriptionA selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdk1/Cdk5) (IC50 = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25). Also shown to inhibit glycogen synthase kinase-3β (GSK-3β) (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM).
FormRed solid
Intert gas (Yes/No) Packaged under inert gas
CAS number40254-90-8
Chemical formulaC₉H₇N₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesOrtega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177.