Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

219478 Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem

219478
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₂N₂O₂S265312-55-8

Products

Catalogue NumberPackaging Qty/Pack
219478-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
Catalogue Number219478
Brand Family Calbiochem®
Synonyms5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine
References
ReferencesRyu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.
Product Information
CAS number265312-55-8
ATP CompetitiveN
FormBlack-purple solid
Hill FormulaC₁₅H₁₂N₂O₂S
Chemical formulaC₁₅H₁₂N₂O₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk4
Primary Target IC<sub>50</sub>6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem Certificates of Analysis

TitleLot Number
219478

References

Reference overview
Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-October-2013 JSW
Synonyms5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine
DescriptionA cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
FormBlack-purple solid
Intert gas (Yes/No) Packaged under inert gas
CAS number265312-55-8
Chemical formulaC₁₅H₁₂N₂O₂S
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesRyu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461.