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219503 Cdk4 Inhibitor V - CAS 943746-57-4 - Calbiochem

219503
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₁₈IN₃O₄943746-57-4

Products

Catalogue NumberPackaging Qty/Pack
219503-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable and metabolically stable (t1/2 >30 min at 37 °C in rat liver microsomes stability assays) pyridinylmethylamino-isoquinoline dione that acts as a potent, ATP-binding site-targeting Cdk4/D1 inhibitor (IC50 = 30 nM) and an effective antiproliferative agent against HCT116 and MCF-7 cancer cells (IC50 = 0.73 and 0.88 µM, respectively), affecting Cdk2/E and Cdk1/B only at much higher concentrations (IC50 = 1.6 and 25.3 µM, respectively).
Catalogue Number219503
Brand Family Calbiochem®
Synonyms4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione
References
ReferencesTsou, H.R., et al. 2009. J. Med. Chem. 52, 2289.
Product Information
CAS number943746-57-4
FormCaramel powder
Hill FormulaC₁₉H₁₈IN₃O₄
Chemical formulaC₁₉H₁₈IN₃O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdk4 Inhibitor V - CAS 943746-57-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Tsou, H.R., et al. 2009. J. Med. Chem. 52, 2289.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2012 JSW
Synonyms4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione
DescriptionA cell-permeable and metabolically stable (t1/2 >30 min at 37 °C in the presence of rat liver microsomes, NADPH, and UDPGA) pyridinylmethylamino-isoquinoline dione that acts as a potent, ATP-binding site-targeting inhibitor against Cdk4/D1 kinase activity (IC50 = 30 nM in cell-free Rb c-terminal fragment phosphorylation assays) and an effective antiproliferative agent against HCT116 colorectal and MCF-7 breast cancer cultures (IC50 = 0.73 and 0.88 µM, respectively), while affecting Cdk2/E and Cdk1/B kinase activities only at much higher concentrations (IC50 = 1.6 and 25.3 µM, respectively).
FormCaramel powder
Intert gas (Yes/No) Packaged under inert gas
CAS number943746-57-4
Chemical formulaC₁₉H₁₈IN₃O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesTsou, H.R., et al. 2009. J. Med. Chem. 52, 2289.