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238811 Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem

238811
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₉H₁₀N₆O140651-18-9

Products

Catalogue NumberPackaging Qty/Pack
238811-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.
Catalogue Number238811
Brand Family Calbiochem®
Synonyms4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
References
ReferencesKrystof, V., et al. 2006. J. Med. Chem. 49, 6500.
Product Information
CAS number140651-18-9
ATP CompetitiveY
FormOrange solid
Hill FormulaC₉H₁₀N₆O
Chemical formulaC₉H₁₀N₆O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk9
Primary Target IC<sub>50</sub>350 nM, using Cdk9/T1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem Certificates of Analysis

TitleLot Number
238811

References

Reference overview
Krystof, V., et al. 2006. J. Med. Chem. 49, 6500.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-August-2007 JSW
Synonyms4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
DescriptionA cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number140651-18-9
Chemical formulaC₉H₁₀N₆O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesKrystof, V., et al. 2006. J. Med. Chem. 49, 6500.