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219556 Ceranib-2 - Calbiochem

219556
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₅H₁₉NO₃

Products

Catalogue NumberPackaging Qty/Pack
219556-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable, potent inhibitor of ceramidase (IC50 = 28 µM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC50 = 730 nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50 mg/kg) without affecting the total body weight.
Catalogue Number219556
Brand Family Calbiochem®
SynonymsCeranib 2, Ceranib2, 3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one, AC Inhibitor III, Acid Ceramidase Inhibitor III
References
ReferencesDraper, J., et al. 2011, Mol. Cancer Ther. 10, 2052.
Product Information
FormWhite powder
Hill FormulaC₂₅H₁₉NO₃
Chemical formulaC₂₅H₁₉NO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Ceranib-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ceranib-2 - Calbiochem Certificates of Analysis

TitleLot Number
219556

References

Reference overview
Draper, J., et al. 2011, Mol. Cancer Ther. 10, 2052.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-May-2012 JSW
SynonymsCeranib 2, Ceranib2, 3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one, AC Inhibitor III, Acid Ceramidase Inhibitor III
DescriptionA cell-permeable, potent inhibitor of ceramidase (IC50 = 28 µM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC50 = 730 nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50 mg/kg) without affecting the total body weight.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₅H₁₉NO₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml; clear, pale yellow solution)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDraper, J., et al. 2011, Mol. Cancer Ther. 10, 2052.