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220285 Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem

220285
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₁H₁₈NO₄Cl3895-92-9

Products

Catalogue NumberPackaging Qty/Pack
220285-5MG Plastic ampoule 5 mg
Description
OverviewNaturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
Catalogue Number220285
Brand Family Calbiochem®
References
ReferencesKandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Barg, J., et al. 1992. J. Neurochem. 59, 1145.
Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
Walterova, D., et al. J. Med. Chem. 24, 1100.
Product Information
CAS number3895-92-9
ATP CompetitiveN
FormLight yellow to yellow solid
Hill FormulaC₂₁H₁₈NO₄Cl
Chemical formulaC₂₁H₁₈NO₄Cl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>660 nM
Purity≥97% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSFL9200000
Safety Information
R PhraseR: 20/21/22-36/37/38

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem Certificates of Analysis

TitleLot Number
220285

References

Reference overview
Kandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Barg, J., et al. 1992. J. Neurochem. 59, 1145.
Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
Walterova, D., et al. J. Med. Chem. 24, 1100.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2008 RFH
DescriptionNaturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
FormLight yellow to yellow solid
CAS number3895-92-9
RTECSFL9200000
Chemical formulaC₂₁H₁₈NO₄Cl
Structure formulaStructure formula
Purity≥97% by NMR
SolubilityDMSO (10 mg/ml) or H₂O (1 mg/ml). Heating to 40-50°C with gentle agitation may be necessary to achieve complete solubilization. Further dilute with buffer just prior to use.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Harmful
Merck USA index14, 2051
ReferencesKandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Barg, J., et al. 1992. J. Neurochem. 59, 1145.
Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
Walterova, D., et al. J. Med. Chem. 24, 1100.