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220486 Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

220486
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₀H₁₄ClN₃O₂516480-79-8

Products

Catalogue NumberPackaging Qty/Pack
220486-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. Also available as a 25 mM solution in DMSO (Cat. No. 220491).
Catalogue Number220486
Brand Family Calbiochem®
Synonyms2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
References
ReferencesArienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.
Product Information
CAS number516480-79-8
ATP CompetitiveY
FormPale yellow solid
Hill FormulaC₂₀H₁₄ClN₃O₂
Chemical formulaC₂₀H₁₄ClN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetChk2
Primary Target IC<sub>50</sub>15 nM; Ki = 37 nM inhibiting Chk2; EC50 = 3 µM and 7.6 µM in rescuing both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis
Primary Target K<sub>i</sub>37 nM inhibiting Chk2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem Certificates of Analysis

TitleLot Number
220486

References

Reference overview
Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-December-2009 RFH
Synonyms2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
DescriptionA cell-permeable, potent, reversible and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC50 = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number516480-79-8
Chemical formulaC₂₀H₁₄ClN₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesArienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.