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233165 Clioquinol - CAS 130-26-7 - Calbiochem

233165
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₉H₅ClINO130-26-7

Products

Catalogue NumberPackaging Qty/Pack
233165-1GM Plastic Bag(s) 1 gm
Description
OverviewA metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu2+ and Zn2+ that stud these deposits. Shown to increase distal dominant axonopathy in animal models.
Catalogue Number233165
Brand Family Calbiochem®
Synonyms5-Chloro-7-iodo-8-hydroxyquinoline
References
ReferencesMelov, S. 2002. Trends Neurosci. 25, 121.
Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
Helmuth, L., et al. 2000. Science 290, 1273.
Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.
Product Information
CAS number130-26-7
ATP CompetitiveN
FormSolid
Hill FormulaC₉H₅ClINO
Chemical formulaC₉H₅ClINO
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMetal ion chelator
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSVC5075000
Safety Information
R PhraseR: 42/43-63

May cause sensitization by inhalation and skin contact.
Possible risk of harm to the unborn child.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Clioquinol - CAS 130-26-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Clioquinol - CAS 130-26-7 - Calbiochem Certificates of Analysis

TitleLot Number
233165

References

Reference overview
Melov, S. 2002. Trends Neurosci. 25, 121.
Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
Helmuth, L., et al. 2000. Science 290, 1273.
Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-April-2008 RFH
Synonyms5-Chloro-7-iodo-8-hydroxyquinoline
DescriptionA metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid's ability to clump together, apparently by trapping the Cu2+ and Zn2+ that reduces the build-up of these deposits. Exhibits greater affinity for Cu2+ and Zn2+ than for Ca2+ and Mg2+. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer's disease.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
CAS number130-26-7
RTECSVC5075000
Chemical formulaC₉H₅ClINO
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (20 mg/ml), Ethanol (1 mg/ml) or Methanol (1.5 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 5031
ReferencesMelov, S. 2002. Trends Neurosci. 25, 121.
Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
Helmuth, L., et al. 2000. Science 290, 1273.
Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.