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233552 Cobra Venom Factor, Naja naja kaouthia

233552
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
233552-1MG Plastic ampoule 1 mg
Description
OverviewNative cobra venom factor from Naja naja kaouthia. Glycoprotein composed of three non-identical disulfide-bonded subunits with M.W. of 68 kDa (α), 48 kDa (β), and 30 kDa (γ). Cobra venom factor (CVF) is a structural and functional analog of cobra, as well as mammalian C3. Thus, in the presence of Factor B, Factor D, and Mg2+, CVF can form a stable CVF,Bb complex that is a C3/C5 convertase enzyme; however, the CVF,Bb complex is not susceptible to regulation by Factors H and I. Four to six µg of purified CVF are equal to 1.0 unit of functional activity as measured by the method of Cochrane, et al.
Catalogue Number233552
Brand Family Calbiochem®
SynonymsCobra Venom Anticomplementary Protein
References
ReferencesBogers, W.M., et al. 1993. Eur. J. Immunol. 23, 433.
Fritzinger, D.C., et al. 1992. J. Immunol. 149, 3554.
Muller, B. and Muller-Ruchholtz, W. 1987. Leuk. Res. 11, 461.
Vogel, C.W. and Muller-Eberhard, H.J. 1984. J. Immunol. Methods 73, 203.
Cochrane, C.G., et al. 1970. J. Immunol. 105, 55.
Ballows, M. and Cochrane, C.G. 1969. J. Immunol. 103, 944.
Product Information
Activity≥250 units/ml
DeclarationNot available for sale outside the United States.
FormLiquid
FormulationIn PBS, pH 7.2.
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by SDS-PAGE
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
ContaminantsPhospholipase: none detected
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Harmful
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Cobra Venom Factor, Naja naja kaouthia SDS

Title

Safety Data Sheet (SDS) 

Cobra Venom Factor, Naja naja kaouthia Certificates of Analysis

TitleLot Number
233552

References

Reference overview
Bogers, W.M., et al. 1993. Eur. J. Immunol. 23, 433.
Fritzinger, D.C., et al. 1992. J. Immunol. 149, 3554.
Muller, B. and Muller-Ruchholtz, W. 1987. Leuk. Res. 11, 461.
Vogel, C.W. and Muller-Eberhard, H.J. 1984. J. Immunol. Methods 73, 203.
Cochrane, C.G., et al. 1970. J. Immunol. 105, 55.
Ballows, M. and Cochrane, C.G. 1969. J. Immunol. 103, 944.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-December-2010 JSW
SynonymsCobra Venom Anticomplementary Protein
DescriptionNative cobra venom factor from Naja naja kaouthia. Glycoprotein composed of three nonidentical disulfide-bound subunits with M.W. of 68,000 (α), 48,000 (β), and 30,000 (γ). Cobra Venom Factor (CVF) is a structural and functional analog of cobra, as well as mammalian C3. In the presence of Factor B, Factor D, and Mg2+, CVF can form a stable CVF, Bb complex which is a C3/C5 convertase enzyme; however, the CVF,Bb complex is not susceptible to regulation by Factors H and I. Four to six µg of purified CVF is equal to 1.0 unit of functional activity as measured by the method of Cochrane, et al.
FormLiquid
FormulationIn PBS, pH 7.2.
Concentration Label Please refer to vial label for lot-specific concentration
Purity≥95% by SDS-PAGE
ContaminantsPhospholipase: none detected
Activity≥250 units/ml
Storage ≤ -70°C
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Harmful
ReferencesBogers, W.M., et al. 1993. Eur. J. Immunol. 23, 433.
Fritzinger, D.C., et al. 1992. J. Immunol. 149, 3554.
Muller, B. and Muller-Ruchholtz, W. 1987. Leuk. Res. 11, 461.
Vogel, C.W. and Muller-Eberhard, H.J. 1984. J. Immunol. Methods 73, 203.
Cochrane, C.G., et al. 1970. J. Immunol. 105, 55.
Ballows, M. and Cochrane, C.G. 1969. J. Immunol. 103, 944.