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204883 Complement C1-Esterase Inhibitor, Human

204883
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
204883-1MG Plastic ampoule 1 mg
Description
OverviewNative, human C1-esterase. Single-chain glycoprotein present in normal human serum at 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. The only known inhibitor of activated C1r and C1s complement enzymes. The presence of either hereditary or acquired deficiencies of C1 inhibitor produce susceptibility to recurrent attacks of angioedema.
Catalogue Number204883
Brand Family Calbiochem®
References
ReferencesBowen, B., et al. 2001. Clin. Immunol. 98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.
Product Information
FormLiquid
FormulationIn PBS, pH 7.3, sterile-filtered through a 0.22 µm filter.
PreservativeNone
Quality LevelMQ100
Applications
Application CommentsVariables associated with assay conditions will dictate the proper working dilution.
Biological Information
Biological activity≥80% of C1-esterase inhibitor will bind activated C1s.
Purity≥90% by SDS-PAGE
SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
ContaminantsIgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin: ≤trace amounts
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Complement C1-Esterase Inhibitor, Human SDS

Title

Safety Data Sheet (SDS) 

Complement C1-Esterase Inhibitor, Human Certificates of Analysis

TitleLot Number
204883

References

Reference overview
Bowen, B., et al. 2001. Clin. Immunol. 98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-January-2020 JSW
DescriptionNative, human C1-esterase. Complent C1-esterase inhibitor purified from human plasma. Single chain glycoprotein present in normal human serum at a concentration of 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.
BackgroundSingle chain glycoprotein present in normal human serum at a concentration of 180 μg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.
FormLiquid
FormulationIn PBS, pH 7.3, sterile-filtered through a 0.22 µm filter.
Concentration Label Please refer to vial label for lot-specific concentration
SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity≥90% by SDS-PAGE
ContaminantsIgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin: ≤trace amounts
Biological activity≥80% of C1-esterase inhibitor will bind activated C1s.
PreservativeNone
CommentsVariables associated with assay conditions will dictate the proper working dilution.
Storage ≤ -70°C
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesBowen, B., et al. 2001. Clin. Immunol. 98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.