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234501 Compound 401 - CAS 168425-64-7 - Calbiochem

234501
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₆H₁₅N₃O₂168425-64-7

Products

Catalogue NumberPackaging Qty/Pack
234501-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 µM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts.
Catalogue Number234501
Brand Family Calbiochem®
Synonyms2-(Morpholin-1-yl)pyrimido[2,1-a]isoquinolin-4-one
References
ReferencesBallou, L.M., et al. 2007. J. Biol. Chem. 282, 24463.
Griffin, R.J., et al. 2005. J. Med. Chem. 48, 569.
Product Information
CAS number168425-64-7
FormBeige solid
Hill FormulaC₁₆H₁₅N₃O₂
Chemical formulaC₁₆H₁₅N₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Compound 401 - CAS 168425-64-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Compound 401 - CAS 168425-64-7 - Calbiochem Certificates of Analysis

TitleLot Number
234501

References

Reference overview
Ballou, L.M., et al. 2007. J. Biol. Chem. 282, 24463.
Griffin, R.J., et al. 2005. J. Med. Chem. 48, 569.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-September-2008 RFH
Synonyms2-(Morpholin-1-yl)pyrimido[2,1-a]isoquinolin-4-one
DescriptionA cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 µM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts.
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number168425-64-7
Chemical formulaC₁₆H₁₅N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBallou, L.M., et al. 2007. J. Biol. Chem. 282, 24463.
Griffin, R.J., et al. 2005. J. Med. Chem. 48, 569.