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234505 Compound 56 - CAS 171745-13-4 - Calbiochem

234505
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₈H₁₈BrN₃O₂171745-13-4

Products

Catalogue NumberPackaging Qty/Pack
234505-500UG Plastic ampoule 500 μg
Description
OverviewA cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (IC50 = 6 pM).
Catalogue Number234505
Brand Family Calbiochem®
Synonyms4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
References
ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
Product Information
CAS number171745-13-4
ATP CompetitiveY
DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
FormWhite solid
Hill FormulaC₁₈H₁₈BrN₃O₂
Chemical formulaC₁₈H₁₈BrN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>6 pM against EGFR
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 40

Limited evidence of a carcinogenic effect.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Compound 56 - CAS 171745-13-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Compound 56 - CAS 171745-13-4 - Calbiochem Certificates of Analysis

TitleLot Number
234505

References

Reference overview
Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
Synonyms4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
DescriptionA cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 6 pM).
FormWhite solid
CAS number171745-13-4
Chemical formulaC₁₈H₁₈BrN₃O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (200 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.