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239805 Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem

239805
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₀H₂₀N₂O₃18172-33-3

Products

Catalogue NumberPackaging Qty/Pack
239805-5MG Alu drum 5 mg
Description
OverviewA cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as Thapsigargin (Cat. No. 586005). Inhibits Ca2+ uptake in cultured arterial smooth muscle cells (IC50 = 560 nM). Also known to inhibit sarcoplasmic reticular Ca2+-ATPase that is distinct from actomyosin ATPase.
Catalogue Number239805
Brand Family Calbiochem®
SynonymsCPA
References
ReferencesBadaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
Schaefer, A., et al. 1994. J. Biol. Chem. 269, 8786.
Demaurex, N., et al. 1992. J. Biol. Chem. 267, 2318.
Low, A.M., et al. 1992. Am. J. Physiol. 262, H31.
Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil. 12, 355.
Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
Product Information
CAS number18172-33-3
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₀H₂₀N₂O₃
Chemical formulaC₂₀H₂₀N₂O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCa2+ uptake in cultured arterial musclue cells
Primary Target IC<sub>50</sub>560 nM inhibiting Ca2+ uptake in cultured arterial smooth muscle cells
Purity≥97% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUY8587000
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem Certificates of Analysis

TitleLot Number
239805

References

Reference overview
Badaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
Schaefer, A., et al. 1994. J. Biol. Chem. 269, 8786.
Demaurex, N., et al. 1992. J. Biol. Chem. 267, 2318.
Low, A.M., et al. 1992. Am. J. Physiol. 262, H31.
Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil. 12, 355.
Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-April-2008 RFH
SynonymsCPA
DescriptionA cell-permeable, reversible inhibitor of endoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as thapsigargin. Mobilizes Ca2+ without increasing the levels of Ins(1,4,5)P3. Also known to inhibit sarcoplasmic reticular Ca2+-ATPase that is distinct from actomyosin ATPase. Bay K 8644 (Cat. No. 196878) can reverse the inhibitory effect of cyclopiazonic acid on the refilling of Ca2+ pools that have been depleted by repetitive stimulation with acetylcholine.
FormOff-white solid
CAS number18172-33-3
RTECSUY8587000
Chemical formulaC₂₀H₂₀N₂O₃
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityChloroform (10 mg/ml) or DMSO (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesBadaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
Schaefer, A., et al. 1994. J. Biol. Chem. 269, 8786.
Demaurex, N., et al. 1992. J. Biol. Chem. 267, 2318.
Low, A.M., et al. 1992. Am. J. Physiol. 262, H31.
Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil. 12, 355.
Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.