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240896 Cystatin C, Human Urine - Calbiochem

240896
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Products

Catalogue NumberPackaging Qty/Pack
240896-50UG Plastic ampoule 50 μg
Description
OverviewA low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Thought to be linked to many disease processes including Alzheimer’s disease, hereditary cerebral hemorrhage, and lung cancer.
Catalogue Number240896
Brand Family Calbiochem®
SynonymsPost γ-globulin
References
ReferencesHall, A., et al. 1998. Biochemistry 37, 4071.
Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409.
Product Information
ATP CompetitiveN
FormSolid
FormulationLyophilized from 20 mM NH₄HCO₃.
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetCysteine protease
Purity≥95% by SDS-PAGE
SourcePrepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Cystatin C, Human Urine - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cystatin C, Human Urine - Calbiochem Certificates of Analysis

TitleLot Number
240896

References

Reference overview
Hall, A., et al. 1998. Biochemistry 37, 4071.
Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-June-2008 RFH
SynonymsPost γ-globulin
DescriptionA low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Rapidly and tightly inhibits papain (Ki = 0.26 nM) and cathepsin B (Ki = 4.4 nM). Thought to be linked to many disease processes including Alzheimer's Disease, hereditary cerebral hemorrhage and lung cancer.
FormSolid
FormulationLyophilized from 20 mM NH₄HCO₃.
SourcePrepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity≥95% by SDS-PAGE
Solubility0.1 M sodium acetate buffer, pH 4.5
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.
Toxicity Standard Handling
ReferencesHall, A., et al. 1998. Biochemistry 37, 4071.
Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest. 56, 409.