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110145 D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem

110145
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
3102-57-6C₂₀H₃₉NO₃

Products

Catalogue NumberPackaging Qty/Pack
110145-5MG Plastic ampoule 5 mg
Description
OverviewBiologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A (PP2A). Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress activated protein kinase (SAPK) in HL-60 human promyelocytic cells.
Catalogue Number110145
Brand Family Calbiochem®
SynonymsC₂ Ceramide
References
ReferencesWestwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
Obeid, L.M., et al. 1993. Science 259, 1769.
Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
Product Information
CAS number3102-57-6
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₀H₃₉NO₃
Chemical formulaC₂₀H₃₉NO₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibits cell growth and induces apoptosis in HL-60 cells
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem Certificates of Analysis

TitleLot Number
110145

References

Reference overview
Westwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
Obeid, L.M., et al. 1993. Science 259, 1769.
Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.

Brochure

Title
Bioactive Lipids Technical Bulletin
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
SynonymsC₂ Ceramide
DescriptionBiologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis of HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A. Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress-activated protein (SAP) kinase in HL-60 human promyelocytic cells.
FormWhite to off-white solid
CAS number3102-57-6
Chemical formulaC₂₀H₃₉NO₃
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (25 mg/ml), Ethanol (5 mg/ml) or Methanol (5 mg/ml). When diluting into aqueous solution, sonication may be necessary to achieve a uniform suspension.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.
Toxicity Irritant
ReferencesWestwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
Obeid, L.M., et al. 1993. Science 259, 1769.
Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.