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260960 DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem

260960
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₉H₉NO₅20357-25-9

Products

Catalogue NumberPackaging Qty/Pack
260960-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC50 = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120). Does not affect PKC or Chk2 kinase activities.
Catalogue Number260960
Brand Family Calbiochem®
SynonymsDMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor
References
ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501.
Product Information
CAS number20357-25-9
ATP CompetitiveN
FormBright Yellow solid
Hill FormulaC₉H₉NO₅
Chemical formulaC₉H₉NO₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDNA-PK activity
Primary Target IC<sub>50</sub>15 µM against DNA-PK (DNA-dependent protein kinase) activity
Purity≥90% by GC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem Certificates of Analysis

TitleLot Number
260960

References

Reference overview
Willmore, E., et al. 2004. Blood,103, 4659.
Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-June-2008 RFH
SynonymsDMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor
DescriptionA cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC50 = 15 µM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.
FormBright Yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number20357-25-9
Chemical formulaC₉H₉NO₅
Structure formulaStructure formula
Purity≥90% by GC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501.