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260961 DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem

260961
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₇H₁₅NO₃154447-35-5

Products

Catalogue NumberPackaging Qty/Pack
260961-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable benzochromenone compound that acts as a potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK with an IC50 of 0.23 µM. It is highly selective towards DNA-PK over PI3K-related kinases (IC50 = 13 µM for PI 3-K and > 100 µM for ATM and ATR) and has no effect on PARP-1. Inhibits DNA-PK-mediated, but not PARP-1-mediated, cellular DNA DSB (double strand break) repair and PLDR (potentially lethal damage recovery) following IR (ionizing radiation). Shown to sensitize both proliferating and quiescent cells to IR.
Catalogue Number260961
Brand Family Calbiochem®
SynonymsNU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646
References
ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
Product Information
CAS number154447-35-5
ATP CompetitiveY
FormCrystalline solid
Hill FormulaC₁₇H₁₅NO₃
Chemical formulaC₁₇H₁₅NO₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationDNA-PK Inhibitor II, CAS 154447-35-5, is a cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).
Biological Information
Primary TargetDNA-PK
Primary Target IC<sub>50</sub>0.23 µM against DNA-PK
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem Certificates of Analysis

TitleLot Number
260961

References

Reference overview
Willmore, E., et al. 2004. Blood,103, 4659.
Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-January-2010 RFH
SynonymsNU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646
DescriptionA cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM). Reported to be highly selective for DNA-PK compared to PI3 K-related kinases (IC50 = 13 µM for PI 3-K and > 100 µM for ATM and ATR). Exhibits no inhibitory effect on PARP-1. Shown to inhibit DNA-PK-mediated, but not PARP-1-mediated, cellular DNA double strand break (DSB) repair and potentially lethal damage recovery (PLDR) following ionizing radiation (IR). Also shown to sensitize both proliferating and quiescent cells to IR.
FormCrystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number154447-35-5
Chemical formulaC₁₇H₁₅NO₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (2 mg/ml) or Methanol (700 µg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.