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266785 Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem

266785
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₇H₂₆FN₃OS93076-89-2

Products

Catalogue NumberPackaging Qty/Pack
266785-5MG Plastic ampoule 5 mg
Description
OverviewPotentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin S2 antagonist.
Catalogue Number266785
Brand Family Calbiochem®
SynonymsR59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one
References
ReferencesGoin, M., et al. 1993. FEBS Lett. 316, 68.
Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418.
de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.
Product Information
CAS number93076-89-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₇H₂₆FN₃OS
Chemical formulaC₂₇H₂₆FN₃OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDiacylglycerol Kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem Certificates of Analysis

TitleLot Number
266785

References

Reference overview
Goin, M., et al. 1993. FEBS Lett. 316, 68.
Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418.
de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.

Citations

Title
  • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision16-June-2008 RFH
    SynonymsR59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one
    DescriptionPotentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Potentiates this effect in studies of signal-transducing inositol lipid metabolism. Inhibits human platelet DAG kinase in intact cells (IC50 = 3.6 µM) and in isolated membranes (IC50 = 6.7 µM). In porcine thymus cytosol it inhibits the 80 kDa DAG kinase (IC50 = 10 µM) but has no effect on the 150 kDa DAG kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin-S2 antagonist.
    FormWhite solid
    CAS number93076-89-2
    Chemical formulaC₂₇H₂₆FN₃OS
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (4 mg/ml) or Ethanol (12 mg/ml)
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
    Toxicity Irritant
    ReferencesGoin, M., et al. 1993. FEBS Lett. 316, 68.
    Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418.
    de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.
    Citation
  • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.