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266788 Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem

266788
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₈H₂₅F₂N₃OS120166-69-0

Products

Catalogue NumberPackaging Qty/Pack
266788-5MG Glass bottle 5 mg
Description
OverviewInhibits diacylglycerol kinase in isolated platelet membranes (IC50 = 300 nM) and in intact platelets (IC50 = 120 nM) by binding to the catalytic domain. A more potent analog of diacylglycerol kinase inhibitor I (Cat. No. 266785).
Catalogue Number266788
Brand Family Calbiochem®
SynonymsR59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II
References
ReferencesJiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.
Product Information
CAS number120166-69-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₈H₂₅F₂N₃OS
Chemical formulaC₂₈H₂₅F₂N₃OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDiacylglycerol Kinase
Primary Target IC<sub>50</sub>300 nM and 120 nM against diacylglycerol kinase in isolated platelet membranes and in intact platelets, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem Certificates of Analysis

TitleLot Number
266788

References

Reference overview
Jiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.

Citations

Title
  • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
  • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-March-2009 RFH
    SynonymsR59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II
    DescriptionInhibitor useful for elucidating roles of protein kinase C. Inhibits diacylglycerol (DAG) kinase in isolated platelet membranes (IC50 = 300 nM) and in intact platelets (IC50 = 120 nM). A more potent analog of DAG kinase inhibitor I.
    FormWhite solid
    CAS number120166-69-0
    Chemical formulaC₂₈H₂₅F₂N₃OS
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (12.5 mg/ml)
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Irritant
    ReferencesJiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
    Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
    Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
    de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.
    Citation
  • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
  • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.