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317642 Dipeptidylpeptidase IV Inhibitor IV, K579 - CAS 440100-64-1 - Calbiochem

317642
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₇H₂₄N₆O440100-64-1

Products

Catalogue NumberPackaging Qty/Pack
317642-5MG Glass bottle 5 mg
Description
OverviewA cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.
Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
Catalogue Number317642
Brand Family Calbiochem®
Synonyms(S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV
References
ReferencesTakasaki, K., et al. 2004. Eur. J. Pharmacol. 505, 237.
Takasaki, K., et al. 2004. Eur. J. Pharmacol. 486, 335.
Takasaki, K., et al. 2004. J. Pharmacol. Sci. 95, 291.
Product Information
CAS number440100-64-1
FormLight brown solid
Hill FormulaC₁₇H₂₄N₆O
Chemical formulaC₁₇H₂₄N₆O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Dipeptidylpeptidase IV Inhibitor IV, K579 - CAS 440100-64-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Dipeptidylpeptidase IV Inhibitor IV, K579 - CAS 440100-64-1 - Calbiochem Certificates of Analysis

TitleLot Number
317642

References

Reference overview
Takasaki, K., et al. 2004. Eur. J. Pharmacol. 505, 237.
Takasaki, K., et al. 2004. Eur. J. Pharmacol. 486, 335.
Takasaki, K., et al. 2004. J. Pharmacol. Sci. 95, 291.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-October-2008 JSW
Synonyms(S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV
DescriptionA cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.
FormLight brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number440100-64-1
Chemical formulaC₁₇H₂₄N₆O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (32 mg/ml), Ethanol (6.5 mg/ml), or 1 eq HCl (16 mg/ml)

Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesTakasaki, K., et al. 2004. Eur. J. Pharmacol. 505, 237.
Takasaki, K., et al. 2004. Eur. J. Pharmacol. 486, 335.
Takasaki, K., et al. 2004. J. Pharmacol. Sci. 95, 291.