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324411 Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem

324411
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₇H₃₈NBr1119-97-7

Products

Catalogue NumberPackaging Qty/Pack
324411-500MG Glass bottle 500 mg
Description
OverviewA cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
Catalogue Number324411
Brand Family Calbiochem®
SynonymsTetradecyltrimethylammonium Bromide, Myristyltrimethylammonium Bromide, TTAB
References
ReferencesQuan, A., et al. 2007. Mol. Pharmacol. 72, 1425.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.
Product Information
CAS number1119-97-7
FormWhite solid
Hill FormulaC₁₇H₃₈NBr
Chemical formulaC₁₇H₃₈NBr
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by Titration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 34

Causes burns.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Corrosive
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem Certificates of Analysis

TitleLot Number
324411

References

Reference overview
Quan, A., et al. 2007. Mol. Pharmacol. 72, 1425.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-April-2008 JSW
SynonymsTetradecyltrimethylammonium Bromide, Myristyltrimethylammonium Bromide, TTAB
DescriptionA cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1119-97-7
Chemical formulaC₁₇H₃₈NBr
Purity≥99% by Titration
SolubilityDMSO (10 mg/ml) or H₂O (100 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Corrosive
Merck USA index14, 6336
ReferencesQuan, A., et al. 2007. Mol. Pharmacol. 72, 1425.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.