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324470 E-4031 - CAS 113558-89-7 - Calbiochem

324470
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O113558-89-7

Products

Catalogue NumberPackaging Qty/Pack
324470-5MG Glass bottle 5 mg
Description
OverviewA potent and selective inhibitor of the rapid type of inactivating inward-rectifying K+ current (IK, IR) (IC50 = 10 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity. A specific blocker of HERG channels (IC50 = 7.7 nM).
Catalogue Number324470
Brand Family Calbiochem®
Synonyms4ʹ-[[1-[2-(6-Methyl-2-pyridinyl)ethyl-4-piperidinyl]carbonyl]methanesulfonanilide, 2HCl
References
ReferencesFicker, E., et al. 2000. Am. J. Physiol. 279, H1748.
Ono, K., et al. 2000. J. Physiol. (London) 524 (Pt. 1), 51.
Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol. 22, 67.
Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37.
Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135.
Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1.
West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther. 2, 205.
West, P.D., et al. 1996. Pharmacol. Toxicol. 78, 89.
Product Information
CAS number113558-89-7
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
Chemical formulaC₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibitor of the rapid type of inactivating inward-rectifying K+ current
Primary Target IC<sub>50</sub>10 nM inhibiting the rapid type of inactivating inward-rectifying K+ current
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

E-4031 - CAS 113558-89-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

E-4031 - CAS 113558-89-7 - Calbiochem Certificates of Analysis

TitleLot Number
324470

References

Reference overview
Ficker, E., et al. 2000. Am. J. Physiol. 279, H1748.
Ono, K., et al. 2000. J. Physiol. (London) 524 (Pt. 1), 51.
Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol. 22, 67.
Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37.
Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135.
Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1.
West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther. 2, 205.
West, P.D., et al. 1996. Pharmacol. Toxicol. 78, 89.

Citations

Title
  • Jun Guo, Hongying Gang and Shetuan Zhang. (2006) Molecular Determinants of Cocaine Block of Human Ether-a-go-go-Related Gene Potassium Channels. Journal of Pharmacology and Experimental Therapeutics 317, 865-874.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision10-December-2016 JSW
    Synonyms4ʹ-[[1-[2-(6-Methyl-2-pyridinyl)ethyl-4-piperidinyl]carbonyl]methanesulfonanilide, 2HCl
    DescriptionA potent and selective inhibitor of the inactivating inward-rectifying potassium current (IK,IR) (IC50 = 10 nM). In inside-out patches, E-4031 also blocks ATP sensitive K+ channel (EC50 = 31 µM). A specific blocker of cardiac HERG channels (IC50 = 7.7 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity.
    FormWhite to off-white solid
    CAS number113558-89-7
    Chemical formulaC₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (50 mg/ml) or H₂O (50 mg/ml)
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesFicker, E., et al. 2000. Am. J. Physiol. 279, H1748.
    Ono, K., et al. 2000. J. Physiol. (London) 524 (Pt. 1), 51.
    Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol. 22, 67.
    Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37.
    Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135.
    Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1.
    West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther. 2, 205.
    West, P.D., et al. 1996. Pharmacol. Toxicol. 78, 89.
    Citation
  • Jun Guo, Hongying Gang and Shetuan Zhang. (2006) Molecular Determinants of Cocaine Block of Human Ether-a-go-go-Related Gene Potassium Channels. Journal of Pharmacology and Experimental Therapeutics 317, 865-874.