Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

328008 ERK Inhibitor II, Negative Control, FR180209 - CAS 1177970-73-8 - Calbiochem

328008
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₈H₁₂N₆O1177970-73-8

Products

Catalogue NumberPackaging Qty/Pack
328008-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable Erk Inhibitor II (Cat. No. 328007) structural analog that acts as a isoform-selective Aurora B kinase inhibitor (95% inhibition at 1 µM; [ATP] = 10 µM) with little or no activity against Aurora A or C (0% and 16% inhibition, respectively, at 1 µM; [ATP] = 15 µM), Also shown to inhibit Chk2, IRR/INSRR, and Ack1/TNK2 (% inhibition/[ATP] = 81%/70 µM, 75%/200 µM, and 71%/70 µM, respectively), while exhibiting much reduced or no inhibitory potency toward a panel of 228 other kinases, including Erk1/2.
Catalogue Number328008
Brand Family Calbiochem®
Synonyms5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ol, Chk2 Inhibitor IV, Aurora Kinase Inhibitor XII, Irfin1, Insulin Receptor Family Inhibitor
References
ReferencesAnastassiadis, T., et al. 2013. J. Biol. Chem. 288, In press.
Gao, Y., et al. 2013. Biochem. J. in press.
Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
Product Information
CAS number1177970-73-8
ATP CompetitiveN
FormGreen solid
Hill FormulaC₁₈H₁₂N₆O
Chemical formulaC₁₈H₁₂N₆O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAurora B kinase
Primary Target IC<sub>50</sub>95% inhibition at 10 µM using 1 µM; [ATP]
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

ERK Inhibitor II, Negative Control, FR180209 - CAS 1177970-73-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ERK Inhibitor II, Negative Control, FR180209 - CAS 1177970-73-8 - Calbiochem Certificates of Analysis

TitleLot Number
328008

References

Reference overview
Anastassiadis, T., et al. 2013. J. Biol. Chem. 288, In press.
Gao, Y., et al. 2013. Biochem. J. in press.
Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-March-2013 JSW
Synonyms5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ol, Chk2 Inhibitor IV, Aurora Kinase Inhibitor XII, Irfin1, Insulin Receptor Family Inhibitor
DescriptionA cell-permeable Erk Inhibitor II (Cat. No. 328007) structural analog that acts as a isoform-selective Aurora B kinase inhibitor (95% inhibition at 1 µM; [ATP] = 10 µM) with little or no activity against Aurora A or C (0% and 16% inhibition, respectively, at 1 µM; [ATP] = 15 µM), Also shown to inhibit Chk2, IRR/INSRR, and Ack1/TNK2 (% inhibition/[ATP] = 81%/70 µM, 75%/200 µM, and 71%/70 µM, respectively), while exhibiting much reduced or no inhibitory potency toward a panel of 228 other kinases, including Erk1/2.
FormGreen solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1177970-73-8
Chemical formulaC₁₈H₁₂N₆O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAnastassiadis, T., et al. 2013. J. Biol. Chem. 288, In press.
Gao, Y., et al. 2013. Biochem. J. in press.
Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.