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328009 ERK Inhibitor III - CAS 331656-92-9 - Calbiochem

328009
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₂H₁₀N₆O₅331656-92-9

Products

Catalogue NumberPackaging Qty/Pack
328009-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable furanyl-nitroaminoguanidine ERK-binding (KD = ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
Catalogue Number328009
Brand Family Calbiochem®
References
ReferencesChen, F., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6281.
Product Information
CAS number331656-92-9
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₂H₁₀N₆O₅
Chemical formulaC₁₂H₁₀N₆O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetERK
Primary Target IC<sub>50</sub>KD = ~13 µM against ERK
Purity≥85% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

ERK Inhibitor III - CAS 331656-92-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ERK Inhibitor III - CAS 331656-92-9 - Calbiochem Certificates of Analysis

TitleLot Number
328009

References

Reference overview
Chen, F., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6281.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2011 RFH
DescriptionA cell-permeable furanyl-nitroaminoguanidine ERK-binding (KD of ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number331656-92-9
Chemical formulaC₁₂H₁₀N₆O₅
Structure formulaStructure formula
Purity≥85% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesChen, F., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6281.