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324623 Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem

324623
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₄H₁₁FN₂OS909250-29-9

Products

Catalogue NumberPackaging Qty/Pack
324623-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.
Catalogue Number324623
Brand Family Calbiochem®
Synonyms5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
References
ReferencesMuller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157.
Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024.
Sarli, V., et al. 2005. ChemBioChem 6, 2005.
Product Information
CAS number909250-29-9
FormWhite solid
Hill FormulaC₁₄H₁₁FN₂OS
Chemical formulaC₁₄H₁₁FN₂OS
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Muller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157.
Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024.
Sarli, V., et al. 2005. ChemBioChem 6, 2005.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-February-2008 JSW
Synonyms5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
DescriptionA cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number909250-29-9
Chemical formulaC₁₄H₁₁FN₂OS
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (5 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesMuller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157.
Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024.
Sarli, V., et al. 2005. ChemBioChem 6, 2005.