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|324761-25MG||Glass bottle||25 mg|
|Overview||A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5 nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50 = 80.8 nM), but not O2•- generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1 mg/kg, i.v.).|
|References||Hsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.|
|Structure formula Image|
|Purity||≥99% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
Elastase Inhibitor V - Calbiochem SDS
|Hsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.