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324688 Ellipticine - CAS 519-23-3 - Calbiochem

324688
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₇H₁₄N₂519-23-3

Products

Catalogue NumberPackaging Qty/Pack
324688-10MG 10 mg
Description
OverviewA cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.
Catalogue Number324688
Brand Family Calbiochem®
Synonyms5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
References
ReferencesFroelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
Schwaller, M.A., et al. 1995. J. Biol. Chem. 270, 22709.
Pommier, Y., et al. 1985. Biochemistry 24, 6406.
Product Information
CAS number519-23-3
ATP CompetitiveN
FormBright yellow solid
Hill FormulaC₁₇H₁₄N₂
Chemical formulaC₁₇H₁₄N₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targettopoisomerase 2
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUU8825000
Safety Information
R PhraseR: 23/24/25-40

Toxic by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Ellipticine - CAS 519-23-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ellipticine - CAS 519-23-3 - Calbiochem Certificates of Analysis

TitleLot Number
324688

References

Reference overview
Froelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
Schwaller, M.A., et al. 1995. J. Biol. Chem. 270, 22709.
Pommier, Y., et al. 1985. Biochemistry 24, 6406.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-January-2013 JSW
Synonyms5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
DescriptionA topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.
FormBright yellow solid
CAS number519-23-3
RTECSUU8825000
Chemical formulaC₁₇H₁₄N₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 3548
ReferencesFroelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
Schwaller, M.A., et al. 1995. J. Biol. Chem. 270, 22709.
Pommier, Y., et al. 1985. Biochemistry 24, 6406.