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329600 Erastin - CAS 571203-78-6 - Calbiochem

329600
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₃₀H₃₁ClN₄O₄571203-78-6

Products

Catalogue NumberPackaging Qty/Pack
329600-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).
Catalogue Number329600
Brand Family Calbiochem®
Synonyms2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one
References
ReferencesYagoda, N., et al. 2007. Nature 447, 864.
Product Information
CAS number571203-78-6
FormWhite solid
Hill FormulaC₃₀H₃₁ClN₄O₄
Chemical formulaC₃₀H₃₁ClN₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationErastin, CAS 571203-78-6, is a cell-permeable compound that binds to VDAC to alter its gating. Induces non-apoptotic cell death in tumor cells harboring activating mutations in RAS-RAF-MEK signaling.
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Erastin - CAS 571203-78-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Erastin - CAS 571203-78-6 - Calbiochem Certificates of Analysis

TitleLot Number
329600

References

Reference overview
Yagoda, N., et al. 2007. Nature 447, 864.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-January-2008 JSW
Synonyms2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one
DescriptionA cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number571203-78-6
Chemical formulaC₃₀H₃₁ClN₄O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesYagoda, N., et al. 2007. Nature 447, 864.