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341310 FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem

341310
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₃₁H₂₆N₂O₃300657-03-8

Products

Catalogue NumberPackaging Qty/Pack
341310-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
Catalogue Number341310
Brand Family Calbiochem®
Synonymsadipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
References
ReferencesFuruhashi, M., et al. 2007. Nature 447, 959.
Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.
Product Information
CAS number300657-03-8
FormWhite solid
Hill FormulaC₃₁H₂₆N₂O₃
Chemical formulaC₃₁H₂₆N₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem Certificates of Analysis

TitleLot Number
341310

References

Reference overview
Furuhashi, M., et al. 2007. Nature 447, 959.
Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-October-2008 JSW
Synonymsadipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
DescriptionA cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number300657-03-8
Chemical formulaC₃₁H₂₆N₂O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml), Methanol (50 mg/ml), or Ethanol (20 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesFuruhashi, M., et al. 2007. Nature 447, 959.
Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.