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341607 FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem

341607
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₈H₄₁N₇O₃219580-11-7

Products

Catalogue NumberPackaging Qty/Pack
341607-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable pyridopyrimidine compound that acts as a potent, ATP-competitive, and reversible inhibitor of FGF and VEGF receptors (IC50 = 21.5 nM for FGFR1). It inhibits PDGFR and c-Src only at much higher concentration (IC50 = 17.6 µM, 19.8 µM, respectively) and exhibits little effect against EGFR, InsR, MEK, and cPKC even at concentrations as high as 50 µM. Shown to inhibit the autophosphorylation of endogenous FGFR1 (IC50 <5 nM) and overexpressed VEGFR2 (IC50 <200 nM) in NIH3T3 cells in vitro, and FGF- and VEGF-induced angiogenesis in mice in vivo.
Catalogue Number341607
Brand Family Calbiochem®
Synonyms1-t-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)-pyrido[2,3-d]pyrimidin-7-yl)urea, PD173074, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XX
References
ReferencesKoziczak, M., et al. 2004. Oncogene 23, 3501.
Trudel, S., et al. 2004. Blood 103, 3521.
Skaper, S.D., et al. 2000. J. Neurochem. 75, 1520.
Mohammadi, M., et al. 1998. EMBO J. 17, 5896.
Product Information
CAS number219580-11-7
FormYellow solid
Hill FormulaC₂₈H₄₁N₇O₃
Chemical formulaC₂₈H₄₁N₇O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem Certificates of Analysis

TitleLot Number
341607

References

Reference overview
Koziczak, M., et al. 2004. Oncogene 23, 3501.
Trudel, S., et al. 2004. Blood 103, 3521.
Skaper, S.D., et al. 2000. J. Neurochem. 75, 1520.
Mohammadi, M., et al. 1998. EMBO J. 17, 5896.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-May-2011 RFH
Synonyms1-t-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)-pyrido[2,3-d]pyrimidin-7-yl)urea, PD173074, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XX
DescriptionA cell-permeable pyridopyrimidine compound that acts as a potent, ATP-competitive, and reversible inhibitor of FGF and VEGF receptors (IC50 = 21.5 nM for FGFR1). It inhibits PDGFR and c-Src only at much higher concentration (IC50 = 17.6 µM, 19.8 µM, respectively) and exhibits little effect against EGFR, InsR, MEK, and cPKC even at concentrations as high as 50 µM. Shown to inhibit the autophosphorylation of endogenous FGFR1 (IC50 <5 nM) and overexpressed VEGFR2 (IC50 <200 nM) in NIH3T3 cells in vitro, and FGF- and VEGF-induced angiogenesis in mice in vivo.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number219580-11-7
Chemical formulaC₂₈H₄₁N₇O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesKoziczak, M., et al. 2004. Oncogene 23, 3501.
Trudel, S., et al. 2004. Blood 103, 3521.
Skaper, S.D., et al. 2000. J. Neurochem. 75, 1520.
Mohammadi, M., et al. 1998. EMBO J. 17, 5896.