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344150 FPT Inhibitor I - Calbiochem

344150
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₉H₂₉NO₆P · 3Na

Products

Catalogue NumberPackaging Qty/Pack
344150-1MG Plastic ampoule 1 mg
Description
OverviewPotent and highly selective inhibitor of farnesyltransferase (FTase; IC50 = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively).
Catalogue Number344150
Brand Family Calbiochem®
Synonyms(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
References
ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₉H₂₉NO₆P · 3Na
Chemical formulaC₁₉H₂₉NO₆P · 3Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFarnesyltransferase (Ftase)
Primary Target IC<sub>50</sub>83 nM against Ftase
Purity≥85% by NMR
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage ≤ -70°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

FPT Inhibitor I - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

FPT Inhibitor I - Calbiochem Certificates of Analysis

TitleLot Number
344150

References

Reference overview
Manne, V., et al. 1995. Drug Development Res. 34, 121.
Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-December-2008 JSW
Synonyms(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
DescriptionA highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 83 nM). Inhibits geranylgeranyltransferase I (IC50 = 26 µM) and II (IC50 = 47 µM) at much higher concentrations.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₉H₂₉NO₆P · 3Na
Structure formulaStructure formula
Purity≥85% by NMR
SolubilityH₂O (≥10 mg/ml)
Storage ≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
Toxicity Standard Handling
ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.