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344510 FTase Inhibitor I - Calbiochem

344510
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₃₈N₄O₃S₂

Products

Catalogue NumberPackaging Qty/Pack
344510-1MG Plastic ampoule 1 mg
Description
OverviewA potent, cell-permeable, selective, peptidomimetic inhibitor of farnesyltransferase (FTase) that is approximately 37-fold more active against FTase (IC50 = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC50 = 790 nM). Very resistant to proteolysis.
Catalogue Number344510
Brand Family Calbiochem®
SynonymsN-[2(S)-[2(R)-Amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH, B581
References
ReferencesYamaguchi, M., et al. 2004. Stroke 35, 1750.
Cox, A.D., et al. 1994. J. Biol. Chem. 269, 19203.
Garcia, A.M., et al. 1993. J. Biol. Chem. 268, 18415.
Product Information
ATP CompetitiveN
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₂₂H₃₈N₄O₃S₂
Chemical formulaC₂₂H₃₈N₄O₃S₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFTase
Primary Target IC<sub>50</sub>21 nM against FTase in vitro
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

FTase Inhibitor I - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

FTase Inhibitor I - Calbiochem Certificates of Analysis

TitleLot Number
344510

References

Reference overview
Yamaguchi, M., et al. 2004. Stroke 35, 1750.
Cox, A.D., et al. 1994. J. Biol. Chem. 269, 19203.
Garcia, A.M., et al. 1993. J. Biol. Chem. 268, 18415.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2008 RFH
SynonymsN-[2(S)-[2(R)-Amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH, B581
DescriptionA potent, cell-permeable inhibitor of farnesyltransferase (FTase) that is about 37-fold more active against FTase (IC50 = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC50 = 790 nM). Very resistant to proteolysis.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₃₈N₄O₃S₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYamaguchi, M., et al. 2004. Stroke 35, 1750.
Cox, A.D., et al. 1994. J. Biol. Chem. 269, 19203.
Garcia, A.M., et al. 1993. J. Biol. Chem. 268, 18415.