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344220 Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ - Calbiochem

344220
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₆₁H₆₅N₁₅O₆

Products

Catalogue NumberPackaging Qty/Pack
344220-5MG Plastic ampoule 5 mg
Description
OverviewA Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
Catalogue Number344220
Brand Family Calbiochem®
SynonymsH₂N-WRWWWW-CONH₂, FPRL1 Antagonist, WRW⁴
References
ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₆₁H₆₅N₁₅O₆
Chemical formulaC₆₁H₆₅N₁₅O₆
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetFormyl Peptide Receptor-Like 1 (FPRL1)
Primary Target IC<sub>50</sub>230 nM for FPRL1 Agonist
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ - Calbiochem Certificates of Analysis

TitleLot Number
344220

References

Reference overview
Bae, Y.S., et al. 2004. J. Immunol. 173, 607.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-June-2008 RFH
SynonymsH₂N-WRWWWW-CONH₂, FPRL1 Antagonist, WRW⁴
DescriptionA Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca2+]i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₆₁H₆₅N₁₅O₆
Peptide SequenceH-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.