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345885 GGTI-2147 - CAS 191102-87-1 - Calbiochem

345885
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₈H₃₀N₄O₃191102-87-1

Products

Catalogue NumberPackaging Qty/Pack
345885-250UG Plastic ampoule 250 μg
Description
OverviewA cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50 value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 > 30 µM for H-Ras).
Catalogue Number345885
Brand Family Calbiochem®
Synonyms4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
References
ReferencesBernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.
Product Information
CAS number191102-87-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₈H₃₀N₄O₃
Chemical formulaC₂₈H₃₀N₄O₃
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGGTase-I
Primary Target IC<sub>50</sub>500 nM in blocking the geranyl-geranylation of Rap1A
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

GGTI-2147 - CAS 191102-87-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GGTI-2147 - CAS 191102-87-1 - Calbiochem Certificates of Analysis

TitleLot Number
345885

References

Reference overview
Bernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
Synonyms4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
DescriptionMethyl ester derivative of GGTI-2133 (Cat. No. 345884). A potent and selective non-thiol inhibitor of geranylgeranyltransferase I (GGTase I) over farnesyltransferase (FTase) in whole cells. Blocks the geranylgeranylation of Rap1A with an IC50 value greater than 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 <30 µM for H-Ras).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number191102-87-1
Chemical formulaC₂₈H₃₀N₄O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.