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361540 GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

361540
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₀H₁₀N₂SO₂327036-89-5

Products

Catalogue NumberPackaging Qty/Pack
361540-5MG Plastic ampoule 5 mg
Description
OverviewA thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). Binds to the active site of GSK-3β.
Catalogue Number361540
Brand Family Calbiochem®
SynonymsTDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
References
ReferencesGuzman, M.L., et al. 2007. Blood 110, 4436.
Barry, F.A., et al. 2003. FEBS Lett. 553, 173.
Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.
Product Information
CAS number327036-89-5
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₁₀H₁₀N₂SO₂
Chemical formulaC₁₀H₁₀N₂SO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGsk-3β
Primary Target IC<sub>50</sub>2 µM, 673 nM, 1.4-5.5 µM, against GSK-3β, Flt-3, and PKC activities, respectively
Purity≥ 95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem Certificates of Analysis

TitleLot Number
361540

References

Reference overview
Guzman, M.L., et al. 2007. Blood 110, 4436.
Barry, F.A., et al. 2003. FEBS Lett. 553, 173.
Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsTDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
DescriptionA cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3β (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC50 >100 µM). Shown to inhibit collagen- and thrombin-induced platelet aggregation.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number327036-89-5
Chemical formulaC₁₀H₁₀N₂SO₂
Structure formulaStructure formula
Purity≥ 95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGuzman, M.L., et al. 2007. Blood 110, 4436.
Barry, F.A., et al. 2003. FEBS Lett. 553, 173.
Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.