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361570 GSK-3β Inhibitor XXVII - Calbiochem

361570
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₁H₂₃N₇O₃S• 2.5 HCl•5H₂O

Products

Catalogue NumberPackaging Qty/Pack
361570-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable pyridinylpyrazinecarboxamide compound that acts as a highly potent, reversible, and ATP-competitive inhibitor of GSK-3β (Ki = 4.9 nM) with ~110-fold greater selectivity over Cdk2 (Ki = 540 nM). Shows only a trivial effect on the activities of 26-related kinases at much higher doses. Blocks GSK-3β-mediated phosphorylation of Ser396 in stably transfected 3T3 fibroblasts expressing four-repeat tau protein (IC50 = 76 nM). Readily crosses blood-brain barrier and exhibits desirable bioavailability and aqueous solubility.
Catalogue Number361570
Brand Family Calbiochem®
Synonyms3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, HCl
References
ReferencesBerg. S., et al. 2012. J. Med. Chem. 55, 9107.
Product Information
FormYellow powder
Hill FormulaC₂₁H₂₃N₇O₃S• 2.5 HCl•5H₂O
Chemical formulaC₂₁H₂₃N₇O₃S• 2.5 HCl•5H₂O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationGSK-3β Inhibitor XXVII, CAS 486424-21-9, is a cell-permeable, highly potent, reversible, and ATP-competitive inhibitor of GSK-3β (Ki = 4.9 nM).
Biological Information
Primary TargetGSK-3β
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

GSK-3β Inhibitor XXVII - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK-3β Inhibitor XXVII - Calbiochem Certificates of Analysis

TitleLot Number
361570

References

Reference overview
Berg. S., et al. 2012. J. Med. Chem. 55, 9107.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-August-2013 JSW
Synonyms3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, HCl
DescriptionA cell-permeable pyridinylpyrazinecarboxamide compound that acts as a highly potent, reversible, and ATP-competitive inhibitor of GSK-3β (Ki = 4.9 nM) with ~110-fold greater selectivity over Cdk2 (Ki = 540 nM). Shows only a trivial effect on the activities of 26-related kinases at much higher doses. Blocks GSK-3β-mediated phosphorylation of Ser396 in stably transfected 3T3 fibroblasts expressing four-repeat tau protein (IC50 = 76 nM). Readily crosses blood-brain barrier and exhibits desirable bioavailability and aqueous solubility.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₁H₂₃N₇O₃S• 2.5 HCl•5H₂O
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBerg. S., et al. 2012. J. Med. Chem. 55, 9107.