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361565 GSK3β Inhibitor XIX, IM-12 - Calbiochem

361565
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₂₀FN₃O₂

Products

Catalogue NumberPackaging Qty/Pack
361565-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable indolylmaleimide derivative and SB-216763 analog that acts as a GSK-3β inhibitor, with an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition, and reduces GSK-3β activity to 27% in an enzymatic assay at 3 µM concentration. It is shown to attenuate hNPC (human neural progenitor cells) cell proliferation, and enrich β-catenin around the nucleus of ST14 cells in the same extent of SB-216763. Furthermore, it can mimic the effect of stabilized β-catenin, up-regulates TCF-activity in a luciferase reporter gene assay, and enhances human progenitor cell differentiation.
Catalogue Number361565
Brand Family Calbiochem®
SynonymsIM-12
References
ReferencesSchmole, AC., et al. 2010. Bioorg. Med. Chem. 18, 6785.
Product Information
FormOrange yellow powder
Hill FormulaC₂₂H₂₀FN₃O₂
Chemical formulaC₂₂H₂₀FN₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
SensitivityDMSO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

GSK3β Inhibitor XIX, IM-12 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK3β Inhibitor XIX, IM-12 - Calbiochem Certificates of Analysis

TitleLot Number
361565

References

Reference overview
Schmole, AC., et al. 2010. Bioorg. Med. Chem. 18, 6785.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2011 RFH
SynonymsIM-12
DescriptionA cell-permeable indolylmaleimide derivative and SB-216763 analog that acts as a GSK-3β inhibitor, with an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition, and reduces GSK-3β activity to 27% in an enzymatic assay at 3 µM concentration. It is shown to attenuate hNPC (human neural progenitor cells) cell proliferation, and enrich β-catenin around the nucleus of ST14 cells in the same extent of SB-216763. Furthermore, it can mimic the effect of stabilized β-catenin, up-regulates TCF-activity in a luciferase reporter gene assay, and enhances human progenitor cell differentiation.
FormOrange yellow powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₂₀FN₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSchmole, AC., et al. 2010. Bioorg. Med. Chem. 18, 6785.