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191501 InSolution™ 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem

191501
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₀BrN₃O676596-65-9

Products

Catalogue NumberPackaging Qty/Pack
191501-500UG Glass bottle 500 μg
Description
OverviewA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.
Catalogue Number191501
Brand Family Calbiochem®
References
ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
Product Information
CAS number676596-65-9
FormLiquid
FormulationA 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.
Hill FormulaC₁₅H₁₀BrN₃O
Chemical formulaC₁₅H₁₀BrN₃O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGSK-3β
Primary Target IC<sub>50</sub>18 nM for GSK-3&beta
Purity≥94% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36/37/39

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem Certificates of Analysis

TitleLot Number
191501

References

Reference overview
Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-September-2012 JSW
DescriptionA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.
FormLiquid
FormulationA 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number676596-65-9
Chemical formulaC₁₅H₁₀BrN₃O
Structure formulaStructure formula
Purity≥94% by HPLC
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.