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189826 InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem

189826
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₈H₁₂N₄O₄2353-33-5

Products

Catalogue NumberPackaging Qty/Pack
189826-10MG Glass bottle 10 mg
Description
OverviewA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.
Catalogue Number189826
Brand Family Calbiochem®
SynonymsDecitabine
References
ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
Haaf, T. 1995. Pharmacol. Ther. 65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.
Product Information
CAS number2353-33-5
FormLiquid
FormulationA 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.
Hill FormulaC₈H₁₂N₄O₄
Chemical formulaC₈H₁₂N₄O₄
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥ 98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem Certificates of Analysis

TitleLot Number
189826

References

Reference overview
Eggert, A., et al. 2001. Cancer Res. 61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
Haaf, T. 1995. Pharmacol. Ther. 65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.

Technical Info

Title
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-June-2012 JSW
SynonymsDecitabine
DescriptionA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.
FormLiquid
FormulationA 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number2353-33-5
Chemical formulaC₈H₁₂N₄O₄
Structure formulaStructure formula
Purity≥ 98% by HPLC
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Regulatory Review
ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
Haaf, T. 1995. Pharmacol. Ther. 65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.