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118502 InSolution™ ATM Kinase Inhibitor

118502
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₁H₁₇NO₃S₂

Products

Catalogue NumberPackaging Qty/Pack
118502-2MG Glass bottle 2 mg
Description
Catalogue Number118502
Brand Family Calbiochem®
References
ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
Hickson, I., et al. 2004. Cancer Res. 64, 9152.
Product Information
FormLiquid
FormulationA 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO.
Hill FormulaC₂₁H₁₇NO₃S₂
Chemical formulaC₂₁H₁₇NO₃S₂
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ ATM Kinase Inhibitor SDS

Title

Safety Data Sheet (SDS) 

InSolution™ ATM Kinase Inhibitor Certificates of Analysis

TitleLot Number
118502

References

Reference overview
Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
Hickson, I., et al. 2004. Cancer Res. 64, 9152.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-November-2008 JSW
DescriptionA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
FormLiquid
FormulationA 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₁H₁₇NO₃S₂
Structure formulaStructure formula
Purity≥95% by HPLC
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
Hickson, I., et al. 2004. Cancer Res. 64, 9152.