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124039 InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

124039
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₀H₂₅ClN₂O • HCl925681-41-0

Products

Catalogue NumberPackaging Qty/Pack
124039-2MG Glass bottle 2 mg
Description
OverviewA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound (Cat. No. 124020) is also available.
Catalogue Number124039
Brand Family Calbiochem®
Synonyms10-DEBC HC, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl
References
ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16982.
Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
Product Information
CAS number925681-41-0
FormLiquid
FormulationA 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O.
Hill FormulaC₂₀H₂₅ClN₂O • HCl
Chemical formulaC₂₀H₂₅ClN₂O • HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAkt
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16982.
Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-December-2012 JSW
Synonyms10-DEBC HC, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl
DescriptionA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound (Cat. No. 124020) is also available.
FormLiquid
FormulationA 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
CAS number925681-41-0
Chemical formulaC₂₀H₂₅ClN₂O • HCl
Structure formulaStructure formula
Purity≥97% by HPLC
Storage ≤ -70°C
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity Standard Handling
ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16982.
Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.