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219674 InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

219674
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₈H₁₀F₃NO₃S₂307510-92-5

Products

Catalogue NumberPackaging Qty/Pack
219674-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. The solid form of this compound (Cat. No. 219670) is also available.
Catalogue Number219674
Brand Family Calbiochem®
Synonyms(Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTRinh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone
References
ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
Product Information
CAS number307510-92-5
FormLiquid
FormulationA 50 mM (5 mg/244 µL) solution of CFTR Inhibitor-172 (Cat. No. 219670) in DMSO.
Hill FormulaC₁₈H₁₀F₃NO₃S₂
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCFTR ion-channel
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36/37/39

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (70°C). Aliquots are stable for up to 3 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem Certificates of Analysis

TitleLot Number
219674

References

Reference overview
Yang, H., et al. 2003. J. Biol. Chem. 278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-December-2012 JSW
Synonyms(Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTRinh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone
DescriptionA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. The solid form of this compound (Cat. No. 219670) is also available.
FormLiquid
FormulationA 50 mM (5 mg/244 µL) solution of CFTR Inhibitor-172 (Cat. No. 219670) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number307510-92-5
Structure formulaStructure formula
Purity≥95% by HPLC
Storage ≤ -70°C
Hygroscopic
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (70°C). Aliquots are stable for up to 3 months at -70°C.
Toxicity Irritant
ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.