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219675 InSolution™ CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem

219675
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
219675-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
Catalogue Number219675
Brand Family Calbiochem®
SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
References
ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
Product Information
CAS number328541-79-3
FormLiquid
FormulationA 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.
Hill FormulaC₁₉H₁₅Br₂N₃O₃
Chemical formulaC₁₉H₁₅Br₂N₃O₃
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCFTR
Primary Target K<sub>i</sub>4.3 µ
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem Certificates of Analysis

TitleLot Number
219675

References

Reference overview
Sonawane, N.D., et al. 2006. FASEB J. 20, 130.
Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-March-2013 JSW
SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
DescriptionA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
FormLiquid
FormulationA 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number328541-79-3
Chemical formulaC₁₉H₁₅Br₂N₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
Storage ≤ -70°C
Hygroscopic
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C.
Toxicity Irritant
ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.