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218861 InSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem

218861
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₉H₄Br₄O₂934358-00-6

Products

Catalogue NumberPackaging Qty/Pack
218861-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC50 = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.
Catalogue Number218861
Brand Family Calbiochem®
Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
References
ReferencesPagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.
Product Information
CAS number934358-00-6
FormLiquid
FormulationA 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.
Hill FormulaC₉H₄Br₄O₂
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCKII
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem Certificates of Analysis

TitleLot Number
218861

References

Reference overview
Pagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-September-2012 JSW
Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
DescriptionA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC50 = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.
FormLiquid
FormulationA 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number934358-00-6
Structure formulaStructure formula
Purity≥90% by HPLC
Storage ≤ -70°C
Hygroscopic
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesPagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.