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344096 InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

344096
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₄H₂₅FNNaO₄93957-55-2

Products

Catalogue NumberPackaging Qty/Pack
344096-10MG Glass bottle 10 mg
Description
OverviewA synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.
Catalogue Number344096
Brand Family Calbiochem®
Synonyms(±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium
References
ReferencesYamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
Ikeda, U., et al. 2000. Hypertension 36, 325.
Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
Yuan, J., et al. 1991. Atherosclerosis 87, 147.
Product Information
CAS number93957-55-2
FormLiquid
FormulationA 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.
Hill FormulaC₂₄H₂₅FNNaO₄
Chemical formulaC₂₄H₂₅FNNaO₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHMG-CoA reductase
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Yamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
Ikeda, U., et al. 2000. Hypertension 36, 325.
Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
Yuan, J., et al. 1991. Atherosclerosis 87, 147.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2013 JSW
Synonyms(±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium
DescriptionA synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.
FormLiquid
FormulationA 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
CAS number93957-55-2
Chemical formulaC₂₄H₂₅FNNaO₄
Structure formulaStructure formula
Purity≥98% by HPLC
Storage ≤ -70°C
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity Standard Handling
ReferencesYamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
Ikeda, U., et al. 2000. Hypertension 36, 325.
Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
Yuan, J., et al. 1991. Atherosclerosis 87, 147.