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361552 InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

361552
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₆H₁₀BrN₃O₂667463-62-9

Products

Catalogue NumberPackaging Qty/Pack
361552-500UG Plastic ampoule 500 μg
Description
Catalogue Number361552
Brand Family Calbiochem®
References
ReferencesPolychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Sato, N., et al. 2004. Nat. Med. 10, 55.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
Product Information
CAS number667463-62-9
ATP CompetitiveY
FormLiquid
FormulationA 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
Hill FormulaC₁₆H₁₀BrN₃O₂
Chemical formulaC₁₆H₁₀BrN₃O₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGSK-3α/β
Primary Target IC<sub>50</sub>5 nM against GSK-3α/β
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem Certificates of Analysis

TitleLot Number
361552

References

Reference overview
Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Sato, N., et al. 2004. Nat. Med. 10, 55.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2008 JSW
DescriptionA cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk's (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).
FormLiquid
FormulationA 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number667463-62-9
Chemical formulaC₁₆H₁₀BrN₃O₂
Structure formulaStructure formula
Purity≥97% by HPLC
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Carcinogenic / Teratogenic
ReferencesPolychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Sato, N., et al. 2004. Nat. Med. 10, 55.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors